An exciting new HIV prevention option is arriving in South Africa called lenacapavir – or LEN – that avoids the need to take daily PrEP pills.
Here’s what you need to know about LEN, how it works, and where you can get it in Gauteng.
What is LEN
- LEN is six-monthly injections type of PrEP (Pre-Exposure Prophylaxis) given to prevent HIV
- When used as prescribed, LEN is more than 96% effective in preventing HIV
- LEN is safe to use
- LEN contains an antiretroviral ingredient called lenacapavir
- It is injected just under the skin on the stomach area or buttocks
Who can use LEN?
Any person who has an HIV-negative test result and weighs 35kg or more.
How do I get started?
When you start using LEN for the first time, you will:
- Receive 2 injections and 2 pills
- Receive 2 pills to take home, to be taken the next day
(NB: The two tablets that you take on day 1 and day 2, must be taken 24 hours apart, not sooner and not later!)
After that, you return to the clinic after 1 month for an HIV test and check-up.
Return to the clinic six months (after your first two injections) for 2 injections and continue doing so every six months.
How soon does it start working?
LEN starts working on day 3 if you received the injection and took 2 tablets on day 1, and 2 tablets on day 2.
Any side effects?
Most people experience injection site reactions (redness, pain, and/or swelling). A small number of people may experience nausea or feel sick. If you experience any of these reactions, the staff at the clinic will assist you.
NB: It is normal to feel a small lump under the skin where the injection was given – this is normal, and you don’t have to be concerned about this.
Why choose LEN?
- It can be kept private
- It is safe
- It is very effective in preventing HIV
- There is no need to remember to use it every day
How does LEN prevent HIV?
Lenacapavir is slowly released into the bloodstream, where it prevents HIV from multiplying.
What does LEN not do?
While LEN prevents HIV, it does not prevent pregnancy or STIs. Condoms and contraception can be used together with LEN if you want to prevent STIs and getting pregnant.
What happens when I stop using LEN
At 28 weeks (6 and a half months) after your last injection, LEN no longer prevents HIV. If you may still be exposed to HIV, you’ll need to use another prevention method such as oral PrEP and/or condoms. Speak to your healthcare provider for guidance on stopping LEN safely.
Where can I get LEN?
- LEN will be available at selected Department of Health clinics from June 2026
- It is not yet available in private clinics or chemists
- For a list of LEN clinics in Gauteng, click here
* Information source: Department of Health * Photo: cottonbro studio / Pexels